To be in the sate of original sin is to be in the state of Scripture calls the “flesh.” This does not refer primarily to things physical, but to a condition of moral corruption. In the flesh we are not able to please God. Indeed we have no desire to please him. We are estranged and alienated from God.
Sproul, R.C.; Grace Unknown: The Heart of Reformed Theology; Baker Books; Grand Rapids, MI; copyright 1997; p. 127